LymphedemaV1, Main, Exploration, bibRecord, 001750

The Impact of Two Semiannual Treatments with Albendazole Alone on Lymphatic Filariasis and Soil-Transmitted Helminth Infections: A Community-Based Study in the Republic of Congo

Identifieur interne : 001750 ( Main/Exploration ); précédent : 001749; suivant : 001751

The Impact of Two Semiannual Treatments with Albendazole Alone on Lymphatic Filariasis and Soil-Transmitted Helminth Infections: A Community-Based Study in the Republic of Congo

Auteurs : Sébastien D. S. Pion ; Cédric B. Chesnais ; Jean Bopda ; Frédéric Louya ; Peter U. Fischer ; Andrew C. Majewski ; Gary J. Weil ; Michel Boussinesq ; François Missamou

Source :

The American Journal of Tropical Medicine and Hygiene [ 0002-9637 ] ; 2015.

RBID : PMC:4426585

Descripteurs français

KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Albendazole (usage thérapeutique), Animaux, Antigènes d'helminthe (immunologie), Antihelminthiques (usage thérapeutique), Ascaridiose (traitement médicamenteux), Ascaridiose (épidémiologie), Ascaris lombricoides (), Ascaris lombricoides (isolement et purification), Congo (épidémiologie), Enfant, Enfant d'âge préscolaire, Femelle, Filariose lymphatique (traitement médicamenteux), Filariose lymphatique (épidémiologie), Helminthiase (parasitologie), Helminthiase (traitement médicamenteux), Helminthiase (épidémiologie), Humains, Infections à ankylostomes (traitement médicamenteux), Infections à ankylostomes (épidémiologie), Jeune adulte, Mâle, Sol (parasitologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Trichocéphalose (traitement médicamenteux), Trichocéphalose (épidémiologie), Trichuris (), Trichuris (isolement et purification), Wuchereria bancrofti (), Wuchereria bancrofti (isolement et purification).
MESH :
- immunologie : Antigènes d'helminthe.
- isolement et purification : Ascaris lombricoides, Trichuris, Wuchereria bancrofti.
- parasitologie : Helminthiase, Sol.
- traitement médicamenteux : Ascaridiose, Filariose lymphatique, Helminthiase, Infections à ankylostomes, Trichocéphalose.
- usage thérapeutique : Albendazole, Antihelminthiques.
- épidémiologie : Ascaridiose, Congo, Filariose lymphatique, Helminthiase, Infections à ankylostomes, Trichocéphalose.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Ascaris lombricoides, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Jeune adulte, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Trichuris, Wuchereria bancrofti.

English descriptors

KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Albendazole (therapeutic use), Animals, Anthelmintics (therapeutic use), Antigens, Helminth (immunology), Ascariasis (drug therapy), Ascariasis (epidemiology), Ascaris lumbricoides (drug effects), Ascaris lumbricoides (isolation & purification), Child, Child, Preschool, Congo (epidemiology), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (epidemiology), Female, Helminthiasis (drug therapy), Helminthiasis (epidemiology), Helminthiasis (parasitology), Hookworm Infections (drug therapy), Hookworm Infections (epidemiology), Humans, Male, Middle Aged, Soil (parasitology), Trichuriasis (drug therapy), Trichuriasis (epidemiology), Trichuris (drug effects), Trichuris (isolation & purification), Wuchereria bancrofti (drug effects), Wuchereria bancrofti (isolation & purification), Young Adult.
MESH :
- chemical , immunology : Antigens, Helminth.
- chemical , parasitology : Soil.
- chemical , therapeutic use : Albendazole, Anthelmintics.
- geographic , epidemiology : Congo.
- drug effects : Ascaris lumbricoides, Trichuris, Wuchereria bancrofti.
- drug therapy : Ascariasis, Elephantiasis, Filarial, Helminthiasis, Hookworm Infections, Trichuriasis.
- epidemiology : Ascariasis, Elephantiasis, Filarial, Helminthiasis, Hookworm Infections, Trichuriasis.
- isolation & purification : Ascaris lumbricoides, Trichuris, Wuchereria bancrofti.
- parasitology : Helminthiasis.
- Adolescent, Adult, Aged, Aged, 80 and over, Animals, Child, Child, Preschool, Female, Humans, Male, Middle Aged, Young Adult.

Abstract

Implementation of mass drug administration (MDA) with ivermectin plus albendazole (ALB) for lymphatic filariasis (LF) has been delayed in central Africa because of the risk of serious adverse events in subjects with high Loa loa microfilaremia. We conducted a community trial to assess the impact of semiannual MDA with ALB (400 mg) alone on LF and soil-transmitted helminth (STH) infections in the Republic of Congo. Evaluation at 12 months showed that ALB MDA had not significantly reduced Wuchereria bancrofti antigenemia or microfilaria (mf) rates in the community (from 17.3% to 16.6% and from 5.3% to 4.2%, respectively). However, the geometric mean mf count in mf-positive subjects was reduced from 202.2 to 80.9 mf/mL (60% reduction, P = 0.01). The effect of ALB was impressive in 38 subjects who were mf-positive at baseline and retested at 12 months: 37% had total mf clearance, and individual mf densities were reduced by 73.0%. MDA also dramatically reduced the hookworm infection rate in the community from 6.5% to 0.6% (91% reduction), with less impressive effects on Ascaris and Trichuris. These preliminary results suggest that semiannual community MDA with ALB is a promising strategy for controlling LF and STH in areas with coendemic loiasis.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426585

DOI: 10.4269/ajtmh.14-0661
PubMed: 25758650
PubMed Central: 4426585

Affiliations:

Le document en format XML

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<author><name sortKey="Pion, Sebastien D S" sort="Pion, Sebastien D S" uniqKey="Pion S" first="Sébastien D. S." last="Pion">Sébastien D. S. Pion</name>
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<author><name sortKey="Chesnais, Cedric B" sort="Chesnais, Cedric B" uniqKey="Chesnais C" first="Cédric B." last="Chesnais">Cédric B. Chesnais</name>
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<author><name sortKey="Fischer, Peter U" sort="Fischer, Peter U" uniqKey="Fischer P" first="Peter U." last="Fischer">Peter U. Fischer</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Albendazole (therapeutic use)</term>
<term>Animals</term>
<term>Anthelmintics (therapeutic use)</term>
<term>Antigens, Helminth (immunology)</term>
<term>Ascariasis (drug therapy)</term>
<term>Ascariasis (epidemiology)</term>
<term>Ascaris lumbricoides (drug effects)</term>
<term>Ascaris lumbricoides (isolation & purification)</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Congo (epidemiology)</term>
<term>Elephantiasis, Filarial (drug therapy)</term>
<term>Elephantiasis, Filarial (epidemiology)</term>
<term>Female</term>
<term>Helminthiasis (drug therapy)</term>
<term>Helminthiasis (epidemiology)</term>
<term>Helminthiasis (parasitology)</term>
<term>Hookworm Infections (drug therapy)</term>
<term>Hookworm Infections (epidemiology)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Soil (parasitology)</term>
<term>Trichuriasis (drug therapy)</term>
<term>Trichuriasis (epidemiology)</term>
<term>Trichuris (drug effects)</term>
<term>Trichuris (isolation & purification)</term>
<term>Wuchereria bancrofti (drug effects)</term>
<term>Wuchereria bancrofti (isolation & purification)</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Albendazole (usage thérapeutique)</term>
<term>Animaux</term>
<term>Antigènes d'helminthe (immunologie)</term>
<term>Antihelminthiques (usage thérapeutique)</term>
<term>Ascaridiose (traitement médicamenteux)</term>
<term>Ascaridiose (épidémiologie)</term>
<term>Ascaris lombricoides ()</term>
<term>Ascaris lombricoides (isolement et purification)</term>
<term>Congo (épidémiologie)</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Filariose lymphatique (traitement médicamenteux)</term>
<term>Filariose lymphatique (épidémiologie)</term>
<term>Helminthiase (parasitologie)</term>
<term>Helminthiase (traitement médicamenteux)</term>
<term>Helminthiase (épidémiologie)</term>
<term>Humains</term>
<term>Infections à ankylostomes (traitement médicamenteux)</term>
<term>Infections à ankylostomes (épidémiologie)</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Sol (parasitologie)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Trichocéphalose (traitement médicamenteux)</term>
<term>Trichocéphalose (épidémiologie)</term>
<term>Trichuris ()</term>
<term>Trichuris (isolement et purification)</term>
<term>Wuchereria bancrofti ()</term>
<term>Wuchereria bancrofti (isolement et purification)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="parasitology" xml:lang="en"><term>Soil</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Albendazole</term>
<term>Anthelmintics</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Congo</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Ascaris lumbricoides</term>
<term>Trichuris</term>
<term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Ascariasis</term>
<term>Elephantiasis, Filarial</term>
<term>Helminthiasis</term>
<term>Hookworm Infections</term>
<term>Trichuriasis</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Ascariasis</term>
<term>Elephantiasis, Filarial</term>
<term>Helminthiasis</term>
<term>Hookworm Infections</term>
<term>Trichuriasis</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'helminthe</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Ascaris lumbricoides</term>
<term>Trichuris</term>
<term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Ascaris lombricoides</term>
<term>Trichuris</term>
<term>Wuchereria bancrofti</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Helminthiase</term>
<term>Sol</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Helminthiasis</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Ascaridiose</term>
<term>Filariose lymphatique</term>
<term>Helminthiase</term>
<term>Infections à ankylostomes</term>
<term>Trichocéphalose</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Albendazole</term>
<term>Antihelminthiques</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Ascaridiose</term>
<term>Congo</term>
<term>Filariose lymphatique</term>
<term>Helminthiase</term>
<term>Infections à ankylostomes</term>
<term>Trichocéphalose</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Animals</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Animaux</term>
<term>Ascaris lombricoides</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Trichuris</term>
<term>Wuchereria bancrofti</term>
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<front><div type="abstract" xml:lang="en"><p>Implementation of mass drug administration (MDA) with ivermectin plus albendazole (ALB) for lymphatic filariasis (LF) has been delayed in central Africa because of the risk of serious adverse events in subjects with high <italic>Loa loa</italic>
 microfilaremia. We conducted a community trial to assess the impact of semiannual MDA with ALB (400 mg) alone on LF and soil-transmitted helminth (STH) infections in the Republic of Congo. Evaluation at 12 months showed that ALB MDA had not significantly reduced <italic>Wuchereria bancrofti</italic>
 antigenemia or microfilaria (mf) rates in the community (from 17.3% to 16.6% and from 5.3% to 4.2%, respectively). However, the geometric mean mf count in mf-positive subjects was reduced from 202.2 to 80.9 mf/mL (60% reduction, <italic>P</italic>
 = 0.01). The effect of ALB was impressive in 38 subjects who were mf-positive at baseline and retested at 12 months: 37% had total mf clearance, and individual mf densities were reduced by 73.0%. MDA also dramatically reduced the hookworm infection rate in the community from 6.5% to 0.6% (91% reduction), with less impressive effects on <italic>Ascaris</italic>
 and <italic>Trichuris</italic>
. These preliminary results suggest that semiannual community MDA with ALB is a promising strategy for controlling LF and STH in areas with coendemic loiasis.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Bopda, Jean" sort="Bopda, Jean" uniqKey="Bopda J" first="Jean" last="Bopda">Jean Bopda</name>
<name sortKey="Boussinesq, Michel" sort="Boussinesq, Michel" uniqKey="Boussinesq M" first="Michel" last="Boussinesq">Michel Boussinesq</name>
<name sortKey="Chesnais, Cedric B" sort="Chesnais, Cedric B" uniqKey="Chesnais C" first="Cédric B." last="Chesnais">Cédric B. Chesnais</name>
<name sortKey="Fischer, Peter U" sort="Fischer, Peter U" uniqKey="Fischer P" first="Peter U." last="Fischer">Peter U. Fischer</name>
<name sortKey="Louya, Frederic" sort="Louya, Frederic" uniqKey="Louya F" first="Frédéric" last="Louya">Frédéric Louya</name>
<name sortKey="Majewski, Andrew C" sort="Majewski, Andrew C" uniqKey="Majewski A" first="Andrew C." last="Majewski">Andrew C. Majewski</name>
<name sortKey="Missamou, Francois" sort="Missamou, Francois" uniqKey="Missamou F" first="François" last="Missamou">François Missamou</name>
<name sortKey="Pion, Sebastien D S" sort="Pion, Sebastien D S" uniqKey="Pion S" first="Sébastien D. S." last="Pion">Sébastien D. S. Pion</name>
<name sortKey="Weil, Gary J" sort="Weil, Gary J" uniqKey="Weil G" first="Gary J." last="Weil">Gary J. Weil</name>
</noCountry>
</tree>
</affiliations>
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The Impact of Two Semiannual Treatments with Albendazole Alone on Lymphatic Filariasis and Soil-Transmitted Helminth Infections: A Community-Based Study in the Republic of Congo

The Impact of Two Semiannual Treatments with Albendazole Alone on Lymphatic Filariasis and Soil-Transmitted Helminth Infections: A Community-Based Study in the Republic of Congo

Source :

Descripteurs français

English descriptors

Abstract

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